منابع مشابه
Mechanisms of Tolerance Induction.
Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important path...
متن کاملMechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective
Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor-derived tissue and organ grafts without administration of life-long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades, substantial cumulative toxicity of combined hematopoietic and tissue transplants precludes wide clinical implementation. Toleran...
متن کاملInduction of Tolerance via the Sublingual Route: Mechanisms and Applications
The clinical efficacy of sublingual immunotherapy (SLIT) with natural allergen extracts has been established in IgE-dependent respiratory allergies to grass or tree pollens, as well as house dust mites. Sublingual vaccines have an excellent safety record, documented with approximately 2 billion doses administered, as of today, in humans. The oral immune system comprises various antigen-presenti...
متن کاملMechanisms of Tolerance Induction by Dendritic Cells In Vivo
Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune responses and tolerance. DCs promote immune tolerance by participating in the negative selection of autoreactive T cells in the thymus. Furthermore, to eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce immune tolerance in the periphery through various mechanisms. Breakdown of th...
متن کاملMechanisms of drought stress tolerance in cool season grasses
Drought stress is one of the most limiting abiotic stresses affecting growth, production and survival of plants in many areas of the world, and is expected to intensify considering the trend of climate change. Grass species are important for the sustainability of agricultural systems, forage resources for animal farming and landscapes. Grass species adapt to water deficit by different morpholog...
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ژورنال
عنوان ژورنال: Annals of Nutrition and Metabolism
سال: 2017
ISSN: 0250-6807,1421-9697
DOI: 10.1159/000457915